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Literature summary extracted from

  • Van Der Meijden, P.E.; Van Schilfgaarde, M.; Van Oerle, R.; Renne, T.; ten Cate, H.; Spronk, H.M.
    Platelet- and erythrocyte-derived microparticles trigger thrombin generation via factor XIIa (2012), J. Thromb. Haemost., 10, 1355-1362.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.38 additional information platelet- and erythrocyte-derived microparticles initiate the formation of thrombin via the activation of factor XII Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.38 factor XI + H2O Homo sapiens
-
 factor XIa + ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
3.4.21.38 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.38 blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.38 factor XI + H2O
-
 Homo sapiens factor XIa + ?
-
 ?
3.4.21.38 Pefachrome + H2O
-
 Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
3.4.21.38 factor XIIa
-
 Homo sapiens
3.4.21.38 FXIIa
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
3.4.21.38 Homo sapiens monocyte-derived microparticles increase FXIIa activity, but to a lesser extent than platelet- and erythrocyte-derived microparticles up